Papers

原著論文

  • Nakadate, H., Aomura, S., Nishimura, A., Reactive astrocytes contribute to decreased blood-brain barrier integrity after impulsive pressure loading in vitro, Journal of Biomechanical Science and Engineering, Vol. 16, No. 2, pp. 21-00075, August 2021.
  • 柴田 惇之介林, 中楯 浩康, 繰り返し電気刺激が細胞の増殖と分化に与える影響, 臨床バイオメカニクス, Vol.42, 233-238, October 2021.
  • 林 成人, 張 月琳, 目片 幸二郎, 中楯 浩康, 太田 耕平, 原 淑惠, 山下 晴央, 中山 伸一, 青村 茂, 甲村 英二, 交通事故による高次脳機能障害症例におけるマルチボディ解析と頭部有限要素解析を組み合わせた損傷予測システムによる受傷状況再現解析の試み, 神経外傷, Vol.42, No.2, pp.195-200, April 2020.
  • Oikawa, S., Matsui, Y., Sayaka, G., Tomoe, K., Takahiro U., Nakadate, H., and Aomura, S., Correlation between acute phase head injury to cyclists and consciousness disturbance: a case study in reconstruction of single-cyclist accident, Journal of Biomechanical Science and Engineering, Vol.14, No.1, 18-00143 (11 pages), May 2019. DOI: https://doi.org/10.1299/jbse.18-00143
  • Oikawa, S., Matsui, Y., Nakadate, H., and Aomura, S., Factors in fatal injuries to cyclists impacted by five types of vehicles, International Journal of Automotive Technology, Vol. 20, No. 1, pp. 197-205, February 2019.
  • Zhang, Y., Miyoshi, K., Han, L., Nakadate, H., Yoneyama, S., Koyama, T., and Aomura, S., Injury risk evaluation of brain concussion in American football based on analysis of accident cases, Advanced Experimental Mechanics, Vol. 3, pp. 203-208, November 2018. DOI: https://doi.org/10.11395/aem.3.0_203
  • 長谷川 純爾, 中楯 浩康, 青村 茂, 頭頚部・有限要素モデルを用いたむち打ち傷害発生メカニズムの解明（後突時の頭頚部・初期挙動再現のための要因検討），日本機械学会論文集, Vol. 84, No. 865, p. 18-00184, August 2018. DOI: https://doi.org/10.1299/transjsme.18-00184
  • 韓 露，張 月琳，中楯 浩康，青村 茂，松井 靖浩，屋内転倒事故における絨毯の頭部防護効果の評価，日本保健科学学会誌, Vol.21，No.1，pp.36-50，June 2018.
  • 韓 露，張 月琳，中楯 浩康，青村 茂，松井 靖浩，屋内転倒事故におけるヘッドバンドの頭部防護効果，日本保健科学学会誌, Vol.20，No.4，pp.175-188，March 2018.
  • Nakadate, H., Zhang, Y., Han, L., Aomura, S. and Matsui, Y., Finite element head model simulation of the case suspected of diffuse axonal injury in the traffic accident, International Journal of Crashworthiness, Vol. 23, No. 2, pp. 182-192, March 2018.
  • Nakadate, H., Kurtoglu, E., Furukawa, H., Oikawa, S., Kakuta, A., and Matsui, Y., Strain-rate dependency of axonal tolerance for uniaxial stretching, Stapp Car Crash Journal, Vol. 61, pp. 53-65, November 2017.
  • Oikawa, S., Nakadate, H., Zhang, Y., Ueno, T., Aomura, S., and Matsui, Y., Finite element analysis of the effectiveness of bicycle helmets in head impacts against roads, Journal of Biomechanical Science and Engineering, Vol.12, No.4, p.17-00175 (11 pages), doi.org/10.1299/jbse.17-00175, September 2017.
  • Nakadate, H., Kurtoglu, E., Koizumi, M., Furukawa, H., Aomura, S. and Kakuta, A., Micro groove structures for directional control of neuronal growth for DAI investigation, Journal of Multidisciplinary Engineering Science and Technology, Vol. 4, No. 5 pp. 7304-7307, May 2017.
  • 張 月琳，韓 露，細野 大樹，松田 雅弘，新田 収，中楯 浩康，紙谷 武，青村 茂，症例の再現解析による柔道時の頭部損傷発症リスクの評価，日本実験力学会誌, Vol.17, No.2 pp.153-161, doi.org/10.11395/jjsem.17.153, July 2017.
  • Kurtoglu, E., Nakadate, H., Kikuta, K., Aomura, S. and Kakuta, A., Uniaxial stretch-induced axonal injury thresholds for axonal dysfunction and disruption and strain rate effects on thresholds for mouse neuronal stem cells, Journal of Biomechanical Science and Engineering, Vol.12, No.1, p.16-00598, doi.org/10.1299/jbse.16-00598, February 2017.
  • 及川 昌子，中楯 浩康，上野 貴浩，青村 茂，松井 靖浩，事故データおよび頭部有限要素モデルを用いた高齢自転車乗員事故様態の解明，ヒューマンインターフェース学会論文誌, Vol.19, No.1, pp.13-23, March 2017.
  • Aomura, S., Zhang, Y., Nakadate, H., Koyama, T. and Nishimura, A., Brain injury risk estimation of collegiate football player based on game video of concussion suspected accident, Journal of Biomechanical Science and Engineering, Vol.11, No.4, p.16-00393, doi:10.1299/jbse.16-00393, October 2016.
  • 柳田 航, 藤江 裕道, 大家 渓, 中楯 浩康, 小泉 宏太, 中村 憲正, 動的ひずみ環境下培養による幹細胞自己生成組織の高強度化, 臨床バイオメカニクス, Vol. 37, pp. 23-28, September 2016.
  • Nakadate, H., Kurtoglu, E., Shirasaki, S., and Aomura, S., Repetitive stretching enhances the formation of neurite swellings in cultured neuronal cells, Integrative Molecular Medicine, Vol.3, No.4, pp.723-728, doi: 10.15761/IMM.1000231, August 2016.
  • Oikawa, S., Matsui, Y., Wakabayashi, A., Gomei, S., Nakadate, H. and Aomura, S., Severity of cyclist head injuries caused by impacts with vehicle structure and road surface, Journal of Biomechanical Science and Engineering, Vol.11, No.2 SI, p.15-00613, doi:10.1299/jbse.15-00613, June 2016.
  • Aomura, S., Nakadate, H., Kaneko, Y., Nishimura, A. and Willinger, R., Stretch-Induced functional disorder of axonal transport in the cultured rat cortex neuron, Integrative Molecular Medicine, Vol.3, No.3, pp.654-660, doi:10.15761/IMM.1000218, May 2016.
  • Ooi, Y., Inui-Yamamoto, C., Suzuki, T., Nakadate, H., Nagase, Y., Seiyama, A., Yoshioka, Y. and Seki, J., In vivo magnetic resonance imaging at 11.7 Tesla visualized the effects of neonatal transection of infraorbital nerve upon primary and secondary trigeminal pathways in rats, Brain research, Vol. 1579, pp. 84-92, September 2014.
  • Nakadate, H., Fukumura, Y., Kaneko, Y., Kakuta, A., Furukawa, H. and Aomura, S., In vitro uniaxial stretch model for evaluating the effect of strain along axon on damage to neurons, Journal of Biomechanical Science and Engineering, Vol.9, No.3, p.14-00136, doi:10.1299/jbse.14-00136, December 2014.
  • Nakadate, H., Inuzuka, K., Akanuma, S., Kakuta, A. and Aomura, S., Effect of amplitude and duration of impulsive pressure on endothelial permeability in in vitro fluid percussion trauma, BioMedical Engineering OnLine, Vol.13, No.1, 44(13pages), doi:10.1186/1475-925X-13-44, April 2014.
  • Nakadate, H., Umahashi, H., Kakuta, A. and Aomura, S., Progression to cell death correlates with neurite swelling induced by stretch injury, Journal of Biomechanical Science and Engineering, Vol.7, No.4, pp.406-415, doi:10.1299/jbse.7.406, November 2012.
  • 中楯 浩康, 青村 茂, 大林 永幸, 新田 収, パワーアシスト型手すり設計のための起立動作シミュレーションモデルの開発, 日本機械学会論文集Ｃ編, 78巻, 794号, 3504-3514頁, doi:10.1299/kikaic.78.3504, 2012年10月.
  • 中楯 浩康, 馬橋 洋人, 張 月琳, 角田 陽, 青村 茂, 二軸引張応力を負荷した培養神経細胞の損傷評価, 日本機械学会論文集Ａ編, 78巻, 791号, 1090-1099頁, doi:10.1299/kikaia.78.1090, 2012年7月.
  • Nakadate, H., Sekizuka, E., Aomura, S. and Minamitani, H., Combinations of hydrostatic pressure and shear stress time-dependently decrease E-selectin, VCAM-1 and ICAM-1 expression induced by tumor necrosis factor-alpha in cultured endothelial cells, Journal of Biomechanical Science and Engineering, Vol.7, No.2, pp.118-129, doi:10.1299/jbse.7.118, March 2012.
  • Zhang, Y., Aomura, S., Nakadate, H., and Fujiwara, S., Study of the mechanism of cerebral contusion based on the real-world brain injury accidents, Journal of Biomechanical Science and Engineering, Vol.6, No.3, pp.191-202, doi:10.1299/jbse.6.191, June 2011.
  • 張 月琳, 青村 茂, 中楯 浩康, 藤原 敏, 局在性脳損傷とびまん性軸策損傷の併発の可能性について, 日本保健科学学会誌 Vol. 13, No. 3, pp. 112-121, December 2010.
  • 中楯 浩康, 関塚 永一, 穂苅 量太, 三浦 総一郎, 南谷 晴之, せん断応力と貫壁性圧力の複合応力が培養血管内皮細胞の細胞接着分子発現に与える影響, 生体医工学, Vol. 47, No. 6, pp. 602-609, Desember 2009.
  • Nakadate, H., Hirose, Y., Sekizuka, E., Minamitani, H., A new in vitro pulsatile perfusion system that mimics physiological transmural pressure and shear stress in any size of in vivo vessel, Journal of Biomechanical Science and Engineering, Vol. 3, No. 1, pp.25-37, February 2009.
  • Ishikawa, M., Kusaka, G., Yamaguchi, N., Sekizuka, E., Nakadate, H., Minamitani H, Shinoda S, Watanabe E., Platelet and leukocyte adhesion in the microvasculature at the cerebral surface immediately after subarachnoid hemorrhage, Neurosurgery, Vol. 64, No. 3, pp. 546-553, March 2009.
  • 南谷晴之, 太田裕貴, 中楯浩康, 小俵麻里子, 関塚永一, 大塩力, 光化学反応刺激による内皮細胞と血小板および白血球接着に対するイブジラストの作用の検討, 日本血栓止血学会誌, Vol. 2, No. 1, pp. 24-32, February 2008.
  • Nakadate, H., Shimizu, T., Uchida, T., Sekizuka, E., Minamitani, H., Ishikawa, M., Oshio, C., Platelet-endothelium interaction and thrombus formation in diabetic microcirculation, Microvascular Reviews and Comminucations, Vol. 47, No. 6, pp. 602-609, Desember 2009.
  • 中楯 浩康，関塚 永一，南谷 晴之, 糖尿病患者におけるレーザ散乱粒子計測法を用いた血小板凝集能測定の有用性, 電気学会論文誌C, Vol. 127, No. 10, pp. 1515-1521, October 2007.
  • Ishikawa, M., Sekizuka, E., Yamaguchi, N., Nakadate, H., Terao, S., Granger, DN., Minamitani H, Angiotensin II type 1 receptor signaling contributes to platelet-leukocyte-endothelial cell interactions in the cerebral microvasculature, American Journal of Physiology Heart and Circulatory Physiology, Vol. 292, No. 5, pp. H2306-H2315, May 2007.
  • 中楯 浩康，内田 祥太，石川 眞実，山口 則之，大塩 力，南谷 晴之，関塚 永一, マルチカラーイメージングを用いた血液流動性測定における新しい観察法, 日本ヘモレオロジー学会誌, Vol. 9, No. 2, pp. 11-14, November 2006.

著　書

  • Zhang, Y., Aomura, S., Nakadate, H., and Fujiwara, S., Study on the Mechanism of Traumatic Brain Injury, Applied Biological Engineering - Principles and Practice, InTech (2012), pp.549-570.

解　説

  • 中楯浩康，青村茂，身体運動の力学解析－臀部離床時の重心に着目した簡易な入力による起立動作シミュレーション－，機械の研究，Vol.70, No.2, pp.109-114, February 2018.
  • 藤田欣也, 中楯浩康, モノ作り論文～構成から失敗体験まで～, 生体医工学, 52巻, 1号, 58-62頁, 2014年2月, doi.org/10.11239/jsmbe.52.58.
  • 青村茂, 中楯浩康, 細胞の状態を“はかる”, 日本機械学会誌, 114巻, 1117号, 876-877頁, 2011年12月.

国際会議発表

  • Hagiwara, M., Kakuta, A., Nakadate, H., Design and analysis of cell manipulation device using vibration and micro shapes, 8th International Conference of Asian Society for Precision Engineering and Nanotechnology, P07, November 14, 2019, Matsue, Japan
  • Hagiwara, M., Kakuta, A., Nakadate, H., Tarao, S., Proposal of cell manipulation device using vibration and micro shapes, 17th International Conference on Precision Engineering, G-1-3, November 2018, Kamakura, Japan
  • Hayashi, S., Nakadate, H., Zhang, Y., Mekata, K., Yamashita, H., Nakayama, S., Kohmura, E., Matsui, Y., Ji, H., Aomura, S., Reproduction analysis of injury condition using finite element modeling of the head in cases with traumatic higher brain dysfunction caused by traffic accidents, ASME 2018 International Mechanical Engineering Congress and Exposition, IMECE2018-86945 November 2018, Pittsburgh, PA
  • Zhang, Y., Yoneyama, S., Nakadate, H., Koyama, T., Matsuda, T., Aomura, S., Construction of a concussion risk estimation system for contact sports, 8th World Congress of Biomechanics, P2220, July 2018, Dublin, Ireland
  • Nakadate, H., Kurtoglu, E., Furukawa, H., Oikawa, S., Kakuta, A., and Matsui, Y., Strain-Rate Dependency of Axonal Tolerance for Uniaxial Stretching, 61st Stapp Car Crash Conference, 2017-03, November 2017, Charleston, South Carolina
  • Nakadate, H., Nakamura, S., Aomura, S., Development of negative pressure loading device with ultra-short duration, XXVI Congress of the International Society of Biomechanics (the 9th Asian-Pacific Conference on Biomechanics), July 2017, Brisbane, Australia
  • Shirasaki, S., Nakadate, H., Aomura, S., Kakuta, A., Development of axonal stretching device for in vitro repetitive mild traumatic brain injury model, XXVI Congress of the International Society of Biomechanics (the 9th Asian-Pacific Conference on Biomechanics), July 2017, Brisbane, Australia
  • Zhang, Y., Yoneyama, S., Nakadate, H., Koyama, T., Aomura, S., Alteration of concussion risk by new and used American football helmets, XXVI Congress of the International Society of Biomechanics (the 9th Asian-Pacific Conference on Biomechanics), July 2017, Brisbane, Australia
  • Nakadate, H., Nakamura, S., Aomura, S., Disruption of capillary-like structure by impulsive pressure loading, SB3C2017 Summer Biomechanics, Bioengineering & Biotransport Conference, June 2017, Tucson, Arizona, USA
  • Shirasaki, S., Nakadate, H., Aomura, S., Kakuta, A., Contribution of repetitive stretching to neurite injury in cortex primary neuronal cells, SB3C2017 Summer Biomechanics, Bioengineering & Biotransport Conference, June 2017, Tucson, Arizona, USA
  • Nakadate, H., Kikuta, K., Kurtoglu, E., Aomura, S., Kakuta, A., Deck, C., Willinger, R., Injury threshold for axonal transport by observation of β-amyloid precursor protein in cultured rat brain neurons exposed to impulsive strain, The 8th Asian-Pacific Conference on Biomechanics (AP Biomech 2015), September 2015, Hokkaido, Japan
  • Furukawa, H., Kakuta, A., Nakadate, H., Aomura, S., Evaluation of effect of impulsive strain and growth direction control of cultured brain neuronal cells, The 8th Asian-Pacific Conference on Biomechanics (AP Biomech 2015), September 2015, Hokkaido, Japan
  • Otsu, E., Kawamata, R., Nakadate, H., Aomura, S., Kakuta, A., Deck, C., Willinger, R., Evaluation of increased endothelial permeability by exposure to impulsive pressure with in vitro blood brain barrier model, The 8th Asian-Pacific Conference on Biomechanics (AP Biomech 2015), September 2015, Hokkaido, Japan
  • Kita, R., Aoki, T., Nakadate, H., Aomura, S., Koyama, T., Zhang, Y., Nicolas Bourdet, Caroline DECK, Remy WILLINGER, Reconstruction simulation of a concussion case of head injury accidents in playing American football,The 8th Asian-Pacific Conference on Biomechanics (AP Biomech 2015), September 2015, Hokkaido, Japan
  • Zhang, Y., Hosono, D., Matsuda, M., Bourdet, N., Nakadate, H., Willnger, R., Aomura, S., Traumatic brain injury criteria in Judo based on reconstruction analysis, The 8th Asian-Pacific Conference on Biomechanics (AP Biomech 2015), September 2015, Hokkaido, Japan
  • Oikawa, O., Matsui, Y., Nakadate, H., Aomura, A., Severity of Cyclist Head Injuries Caused by Impacts with Vehicle Structure and Road Surface, The 8th Asian-Pacific Conference on Biomechanics (AP Biomech 2015), September 2015, Hokkaido, Japan
  • Aomura, S., Nakadate, H., Diagnosis of Axonal Injury by observing the leaked β-APP, The 4th Japan-Switzerland Workshop on Biomechanics, 1-4 September 2014, Shima, Mie, Japan
  • Kita, R., Nakadate, H., Matsui, Y., Aomura, S., Finite element head model simulation of the case suspected of diffuse axonal injury in the traffic accident, International Crashworthiness Conference 2014, 25-28 August 2014, Sarawak, Malaysia
  • Aomura, S., Nakadate, H., Kaneko, S., The Verification of the Case that DAI was Suspected by Simulation of the Actual Traffic Accident, 7th World Congress of Biomechanics, 6-11 July 2014, Boston, MA
  • Nakadate, H., Kaneko, Y., Kikuta, K., Aomura, S., Kakuta, A., Evaluation of Stretch-injured Axon in Brain Neuronal Cell by Observation of β-Amyloid Precursor Protein, 7th World Congress of Biomechanics, 6-11 July 2014, Boston, MA
  • Nakadate, H., Aomura, S., Kakuta, A., An in Vitro Stretch-Injury Model for Elongation-Controlled Neuronal Cells: Effect of Strains Along Neurite, IFMBE Proceedings 43, pp.756-759, The 15th International Conference on Biomedical Engineering, 4-7 December 2013, Singapore.
  • Nakadate, H, Akanuma, S, Aomura, S., Kakuta, A., Impact pressure increases permeability of cultured human endothelial cells, ASME 2012 Summer Bioengineering Conference, SBC2012-80, 20-23 June 2012, Fajardo, Puerto Rico.
  • Nakadate, H., Minamitani, H., Aomura, S., Combination of shear stress and hydrostatic pressure decreases ICAM-1, VCAM- 1 and E-selectin expressions induced by TNF-α in cultured endothelial cells, 5th European Conference of the International Federation for Medical and Biological Engineering,Vol.37, pp.1334-1337, 14-18 September 2011, Budapest, Hungary.
  • Nakadate, H., Minamitani, H., Aomura, S., Combinations of hydrostatic pressure and shear stress influence morphology and adhesion molecules in cultured endothelial cells, 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, pp.3812-3815, 31 August-4 September 2010, Buenos Aires, Argentina.
  • Nakadate, H., Aomura, S., Zhang, Y., Kakuta, A., Fujiwara, S., Strain magnitude and strain rate influence stretch-induced injury of PC12 cells, 6th World Congress of Biomechanics, Vol.31, pp.1091-1094, 1-6 August 2010 ,Singapore.
  • Zhang Y., Aomura S., Nakadate H., Fujiwara S., Study on the mechanism of cerebral contusion based on judicial autopsy report, 6th World Congress of Biomechanics, August 2010 (Singapore),IFMBE Proceedings 31, pp.505-508.
  • Nakadate, H., Sekizuka, E., Oshio, C., Minamitani, H., Effect of antithrombotic agents aspirin, beraprost sodium and heparin on thrombus formation in mesenteric microcirculation of streptozotocin-induced diabetic rats. 24th Conference of the European Society for Microcirculation (Amsterdam, Netherlands), 2006.

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